Considering duration of action, efficacy, resistance to wash-off from bathing or swimming and its ability to halt reproduction of the few fleas resistant to Frontline, Frontline Plus is the the most effective flea control product available. For tick control its superiority is less clear, but when resistance to wash-off and safety are paramount, Frontline is your best choice. Ticks will bite and attach, then die slowly over a period of two or three days. Although scientific studies are lacking, there is reason to believe that Frontline provides useful protection against lyme disease.